CeraBEST® Clinical Studies

References

  1. Jensen JM, Fölster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schütze S, Proksch E. Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J Invest Dermatol. 2004 Jun; 122(6):1423-31.
  2. Di Marzio L, Cinque B, De Simone C, Cifone MG. Effect of the lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. J Invest Dermatol. 1999 Jul; 113(1):98-106.
  3. Wu J, Nilsson A, Jönsson BA, Stenstad H, Agace W, Cheng Y, Duan RD. Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. Biochem J. 2006 Feb 15; 394(Pt 1):299-308.
  4. Di Marzio L, Russo FP, D’Alò S, Biordi L, Ulisse S, Amicosante G, De Simone C, Cifone MG Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities Nutrition and Cancer 2001; 40(2):185-196
  5. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A. Decreased levels of ceramide in stratum corneum of atopic dermatitis : an etiologic factor in atopic dry skin? J Invest Dermatol 1991; 96: 523-526.
  6. Yamamoto A, Serizawa S, Ito M, Sato Y. Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 1991; 283: 219-223.
  7. Di Marzio L, Centi C, Cinque B, Masci S, Giuliani M, Arcieri A, Zicari L, De Simone C, Cifone MG Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients Exp Dermatol 2003; 12:615-620
  1. Lew BL, Cho Y, Kim J, Sim WY, Kim NI. Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-alpha, and JNK. J Korean Med Sci. 2006 Feb; 21(1):95-9.
  2. Cho Y, Lew BL, Seong K, Kim NI. An inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis. J Korean Med Sci. 2004 Dec; 19(6):859-63.
  3. Di Marzio L, Cinque B, Cupelli F, De Simone C, Cifone MG, Giuliani M. Increase of skin-ceramide levels in aged subjects following a short-term topical application of bacterial sphingomyelinase from Streptococcus thermophiles. International J Immunopathol Pharmacol 2008; 21(1)
  4. Lauer-Fields JL, Broder T, Sritharan T, Chung L, Nagase H, Fields GB. Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates. Biochemistry. 2001 May 15; 40(19):5795-803.
  5. Hoeger PH, Schreiner V, Klaassen IA, Enzmann CC, Friedrichs K, Bleck O. Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern in vernix and fetal skin. Br J Dermatol 2002 Feb; 146(2):194-201.
  6. Zoccali G, Cinque B, La Torre C, Lombardi F, Palumbo P, Romano L, Mattei A, Orsini G, Cifone MG, Giuliani M. Improving the outcome of fractional CO2 laser resurfacing using a probiotic skin cream: Preliminary clinical evaluation. Lasers in Medical Sciences, 2016, Epub Jul13