CeraBEST® Efficacy

CERABEST® is a proprietary dermatological cream and lotion containing probiotic lysate based active principles branded as DermaACB®.

DermaACB® is clinically proven to generate ceramides endogeneously / in the skin, by virtue of neutral and alkaline Sphinogomyelinases derived from bacterial lysate (Streptococcus thermophilus):

Neutral Sphingomyelinase hydrolyzes sphingomyelin to generate different subtypes of endogenous ceramides. Neutral Sphingomyelinase from S. thermophilus can generate endogenous ceramides and helps in recovery of certain skin conditions as well as to address age-related changes such as dry skin and wrinkles.

Alkaline Shingomyelinase is known to play a key role in various physiological reactions including the hydrolysis of Platelet Activating Factor (PAF), a crucial mediator for many physiological and pathological reactions such as inflammation. Thus DermaACB has mild anti-inflammatory action as well.

Mild anti-inflammatory effect and endogenous / in vivo production of Ceramides within the skin result in

Reduction in itch associated with certain dermatological condition

Prevention / minimal Trans-Epidermal Water Loss

Ceramides production in skin which are depleted / levels are altered in various skin conditions such as Atopic Dermatitis, Psoriasis, Acne and Blemishes etc

Excellent moisturizer effect

Aqua based formulation for quick absorption

Mild anti-inflammatory effect and endogenous / in vivo production of Ceramides within the skin result in:

  • Reduction in itch associated with certain dermatological conditions
  • Prevention / minimal Trans-Epidermal Water Loss
  • Ceramides production in skin which are depleted / levels are altered in various skin conditions such as Atopic Dermatitis, Psoriasis, Acne and Blemishes etc.
  • Excellent moisturizer effect
  • Aqua based formulation for quick absorption

Ceramide level increased significantly with increasing concentration of S. thermophilus S244 contained DermaACB™ and increasing time of incubation

Adapted from Di Marzio L., et al. J Invest Dermatol, 113:98-106 (1999)

Skin lipid extracts from the forearms of 11 AD patients before (T0) and after (T1) treatment for 2 weeks.

Di Marzio L., et al. Exp Dermatol, 11:1-6 (2003)

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CeraBEST® - Global Status

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Peer Reviewed Clinical Studies

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Registered / launched in Countries

Unique Formulation / Under Potential Patent Protection*

* – Patent under process